There is a lot of debate about using products like Drano - research on line.
It's really helpful to unscrew the gas trap because it prevents corrosion from seizing the connection either metal or PVC and it's a good time to replace any rubber seals.
Once you have the gas trap removed you can remove the tailpiece and use a plastic zip tie to poke through any crud.
If your in an old house with cast iron pipes them thats reason to stay away from harsh acids.
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